p63 is a member of the p53 gene family and encodes for at least six major isotypes with transactivating, death-inducing activities (TAp63) and also dominant-negative activities (deltaNp63). p63 protein is reported to be expressed in a variety of normal human and mouse tissues, including proliferating cells of epithelium, cervix, urothelium and prostate. p63 protein is also reported to be expressed in most poorly differentiated squamous cell carcinomas. In epithelial cells, the dominant isotype, deltaNp63, lacks an acidic N-terminus corresponding to the transactivating domain of p53. The deltaN-isotype is also reported to be abundantly expressed in naso-pharyngeal carcinomas. p63 protein is required for prostate development and, in mice, it is essential for limb and epidermal morphogenesis. The human p63 gene is mutated in children with the disease Ectrodactyly Ectodermal Dysplasia and Facial Clefts syndrome. In contrast to the p53 gene, the p63 gene is rarely mutated in human cancer. p63 protein is reported not to be expressed in prostate adenocarcinoma but altered expression is a frequent event in bladder carcinogenesis.

Product Specific Information

Clone 7JUL is raised to a prokaryotic recombinant fusion protein corresponding to a region (aa319-410) common to six isoforms of the p63 molecule.